TABLE 4:

The most relevant pathways involved in fatostatin-treated HTM cells using lipidomic pathway analysis

Pathways	Total Compound	Hits	Raw p	FDR	Impact
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	14	1	0.17694	0.65345	0.00399
Glycerophospholipid metabolism	36	4	0.40972	0.65345	0.26332
Arachidonic acid metabolism	36	1	0.46277	0.65345	0
Linoleic acid metabolism	5	1	0.46277	0.65345	0
alpha-Linolenic acid metabolism	13	1	0.46277	0.65345	0
Biosynthesis of unsaturated fatty acids	36	1	0.49008	0.65345	0
Sphingolipid metabolism	21	2	0.83211	0.88546	0.26978
Steroid biosynthesis	42	1	0.88546	0.88546	0

The table shows the detailed results for pathways relevant to fatostatin treatment. Columns (left to right) denote the pathway names, the total number of compounds in the pathway (Total Compound), the matched number from the lipidomics data (Hits), the original p value calculated from the enrichment analysis (Raw p), the p-value adjusted using False Discovery Rate (FDR), and the pathway impact value calculated from pathway topology analysis (Impact).