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. Author manuscript; available in PMC: 2024 Jan 30.
Published in final edited form as: J Infect Dis. 2009 Feb 1;199(3):381–390. doi: 10.1086/595830

Figure 1.

Figure 1.

Phylogenetic tree and prevalence of neutralizing antibodies (NAbs) against different adeno-associated virus (AAV) types in 100 serum samples from Australia, 281 from Europe, 407 from Africa, and 100 from the United States. A, Neighbor-joining phylogeny was inferred with Poisson correction for the protein sequences of the AAV VP1 Cap proteins. Scale, evolutionary distance of the number of substitutions per site. B and C, Samples were considered positive if serum dilutions of >1:20 (A) or >1:80 (B) inhibited vector transduction by ≥50%. **Less prevalent than anti-AAV2 Nab (P < .05); ***less prevalent than anti-AAV2 and anti-AAV1 NAbs (P < .05).