Table 2.

Comparison of study design performance as measured by AUROC for each distance measure. Bolded metric values are significantly better than the others.

	Cosine		Euclidean		Gower		Manhattan
Design*	mean	95% CI	mean	95% CI	mean	95% CI	mean	95% CI
A	0.800	0.792, 0.808	0.807	0.800, 0.814	0.791	0.781, 0.800	0.800	0.792, 0.807
B	0.793	0.785, 0.801	0.799	0.792, 0.806	0.784	0.774, 0.794	0.792	0.784, 0.800
C	0.793	0.785, 0.801	0.798	0.791, 0.805	0.783	0.773, 0.793	0.791	0.783, 0.798
D	0.840	0.833, 0.847	0.848	0.842, 0.854	0.864	0.857, 0.872	0.852	0.845, 0.858
E	0.840	0.833, 0.847	0.845	0.839, 0.852	0.852	0.844, 0.860	0.846	0.839, 0.852
F	0.510	0.500, 0.521	0.512	0.503, 0.522	0.494	0.482, 0.507	0.485	0.475, 0.495

^*Real patients (A), digital twins (B), real patients and digital twins (C), closest digital twins (D), real patients and closest digital twins (E), and real patients outside the community (F).