Figure 1:

ICP0 Primary Structure from HSV-1 strain KOS. A) Important domains indicated. RING-finger domain, residues 116–156. Nuclear Localization Sequence (NLS), residues 501–507. USP7 binding domain, residues 619–635. SUMO-interacting motif (SIM)-like sequences (SLS) 5, 6, and 7: residues 652–655 (SLS5), 668–671 (SLS6), and 682–685 (SLS7). CoREST binding domain, residues 667–739. ND10 localization domain, residues 634–768. ICP0 dimerization domain, residues 555–676, with a minimal dimerization domain from 618–712 (red line). B) His-tagged constructs used for structure analyses.