TABLE 1.

Histopathological grading scale for degree of inflammation

Grade	Condition of:
	Bladder	Kidney
0	Normal	Normal
1	Subepithelial cell inflammatory infiltration (focal and multifocal)	Focal inflammation (cellular infiltration and/or edema in the pelvis)
2	Edema and subepithelial inflammatory cell infiltration (diffuse)	Focal inflammation (more severe) from pelvis to medulla, with and without moderate edema
3	Marked subepithelial inflammatory cells with necrosis and neutrophils in and on bladder mucosal epithelium	Multifocal inflammation and cells from pelvis to medulla
4	Inflammatory cell infiltrate extends into muscle in addition to criteria for grade 3	Extensive segmental inflammation and necrosis evident from pelvis to cortex
5	Loss of surface epithelium (necrosis with full-thickness inflammatory cell infiltration)	Diffuse tissue necrosis and inflammatory cell infiltration extending from pelvis to cortex