Table 1:
Genomic loci identified in the MVP cohort for the five personality traits
| Genomi cLocus | uniqID (CHR:Position) | P.value | Start | End | LeadSNPs | Genes | |
|---|---|---|---|---|---|---|---|
| Neuroticism | |||||||
| 1 | 2:58156539:C:T | 7.87E-10 | 57942987 | 58484172 | rs2139053 | VRK2;BCL11A;FANCL | |
| 2 | 7:2076701:C:T | 3.15E-10 | 1932629 | 2110850 | rs6948912 | FTSJ2;MAD1L1;AC110781.3 | |
| 3 | 8:10903475:A:T | 4.39E-12 | 8088230 | 11895484 | rs7825636;rs615632;rs2001433 | TDH;FAM167A;MSRA TDH;FAM167A;MSRA |
|
| 4 | 8:143312933:A:C | 1.80E-15 | 1.43E+08 | 1.44E+08 | rs4129585;rs117713019 | NA | |
| 5 | 11:13328979:C:G | 1.17E-11 | 13230633 | 13350131 | rs7396943 | ARNTL | |
| 6 | 16:61833811:C:T | 3.24E-08 | 61775810 | 61953413 | rs6498809 | CDH8 | |
| 7 | 17:43667635:A:G | 3.95E-14 | 43460181 | 44865603 | rs574307253;rs116956554 | KANSL1;CRHR1;MAPT | |
| Extraversion | |||||||
| 1 | 1:71834574:G:T | 1.13E-08 | 71822831 | 71896762 | rs11209774 | NA | |
| 2 | 2:58167698:G:GA | 1.11E-08 | 57942987 | 58478157 | rs5831479 | VRK2;BCL11A | |
| 3 | 2:185130889:A:G | 1.79E-08 | 1.85E+08 | 1.85E+08 | rs7606514 | NA | |
| 4 | 4:85363489:C:T | 4.81E-08 | 85326010 | 85408000 | rs1444978 | NA | |
| 5 | 5:93008722:C:T | 5.61E-09 | 92977139 | 93427260 | rs1011501 | FAM172A | |
| 6 | 6:92315317:G:T | 4.55E-08 | 92234049 | 92340527 | rs7739331 | NA | |
| 7 | 11:13248730:C:T | 5.64E-10 | 13230633 | 13345926 | rs35424804 | ARNTL | |
| 8 | 12:108618630:C:T | 4.97E-09 | 1.09E+08 | 1.09E+08 | rs3764002 | WSCD2 | |
| 9 | 17:43778680:A:T | 2.42E-09 | 43463493 | 44773783 | rs17688916 | KANSL1;CRHR1;MAPT | |
| 10 | 17:79452756:A:AT | 7.94E-09 | 79429358 | 79473743 | rs35918640 | FSCN2;RP13-766D20.2 | |
| 11 | 19:31876692:A:C | 4.33E-09 | 31830613 | 31885009 | rs12971383 | TSHZ3;AC007796.1 | |
| Agreeableness | |||||||
| 1 | 7:114210814:C:T | 4.00E-10 | 1.14E+08 | 1.14E+08 | rs17137124 | FOXP2;MIR3666 | |
| 2 | 8:10700266:G:T | 4.06E-09 | 10516336 | 11450422 | rs7833945 | TDH;FAM167A;SOX7 | |
| 3 | 18:53195249:A:G | 1.92E-08 | 53195249 | 53463661 | rs7240986 | RP11-397A16.1 | |
| Conscientiousness | |||||||
| 1 | 7:114297180:A:G | 1.51E-08 | 1.14E+08 | 1.14E+08 | rs936145 | FOXP2;MIR3666 | |
| 2 | 8:81443461:A:G | 8.62E-09 | 81358464 | 81443461 | rs78446248 | NA | |
| Openness | |||||||
| 1 | 2:29377923:A:T | 2.03E-08 | 29345180 | 29403624 | rs6725323 | NA | |
| 2 | 4:152945667:C:T | 2.77E-09 | 1.53E+08 | 1.53E+08 | rs919013 | NA | |
| 3 | 6:135928772:G:T | 4.29E-10 | 1.36E+08 | 1.36E+08 | rs117890891 | AHI1 | |
| 4 | 8:65463442:C:T | 3.44E-09 | 65437964 | 65498165 | rs6996198 | ARMC1;RP11-21C4.5;CYP7B1 | |
| 5 | 8:141647291:A:C | 3.92E-08 | 1.42E+08 | 1.42E+08 | rs11996715 | PTK2;TRAPPC9;RP11-809O17.1 | |
| 6 | 9:35777442:G:GTT | 2.56E-08 | 35731560 | 35851048 | rs61689447 | TMEM8B;NPR2;TPM2;GBA2;CREB3;SPAG8 | |
| 7 | 11:66610645:C:G | 2.54E-13 | 66066349 | 66673079 | rs7570 | PC;LRFN4;C11orf80 |