Table 3A:

Outcome of mendelian randomization experiments performed using MR

Trait	Two sample Method	Exposure	Outcome	No. of instruments	Beta	P	Pleiotropy	Heterogeneity
Neuro	IVW	MDD	Neuro	71	0.429	2.07E-85	3.48E-04	248.350
	MR Egger				0.416	2.70E-05		248.274
	Weighed Mean				0.363	4.58E-68
	Simple Mode				0.351	3.10E-09
	Weighed Mode				0.336	3.42E-12
	IVW	Neuro	MDD	114	0.834	6.41E-103	2.55E-05	369.516
	MR Egger				0.791	7.79E-05		369.340
	Weighed Mean				0.734	3.42E-66
	Simple Mode				0.748	1.73E-06
	Weighed Mode				0.704	3.77E-06
	IVW	ANX	Neuro	75	0.179	1.248E-15	0.007	389.419
	MR Egger				−0.002	9.58E-01		307.410
	Weighed Mean				0.101	1.18E-09
	Simple Mode				0.081	9.70E-04
	Weighed Mode				0.081	3.22E-03
	IVW	Neuro	ANX	126	0.700	5.76E-61	−1.17E-03	209.008
	MR Egger				0.766	3.18E-05		208.767
	Weighed Mean				0.706	8.21E-40
	Simple Mode				0.821	2.76E-06
	Weighed Mode				0.854	1.10E-07
Agreeableness	IVW	MDD	Agree	66	−0.284	5.77E-13	9.31E-04	118.501
	MR Egger				−0.273	1.18E-01		118.492
	Weighed Mean				−0.281	5.70E-13
	Simple Mode				−0.376	5.52E-03
	Weighed Mode				−0.376	3.82E-03
	IVW	Agree	MDD	32	−0.221	4.16E-06	−1.17E-02	133.267
	MR Egger				0.127	3.50E-01		106.341
	Weighed Mean				−0.172	6.62E-05
	Simple Mode				−0.261	2.31E-02
	Weighed Mode				−0.234	9.34E-04
	IVW	ANX	Agree	68	−0.241	7.73E-16	−5.40E-03	102.166
	MR Egger				−0.112	1.13E-01		96.094
	Weighed Mean				−0.191	4.01E-07
	Simple Mode				−0.155	7.72E-02
	Weighed Mode				−0.172	4.35E-02
	IVW	Agree	ANX	42	−0.224	1.15E-08	−5.07E-03	52.159
	MR Egger				−0.068	6.05E-01		50.235
	Weighed Mean				−0.198	1.43E-04
	Simple Mode				−0.188	1.39E-01
	Weighed Mode				−0.192	1.26E-01