FIG. 8.

Sequence comparisons of orthologous immune modulator pairs of RhCMV and HCMV. Sequences of Rh182 (RhUS2), Rh184 (RhUS3), Rh185 (RhUS6), and Rh189 (RhUS11) were aligned with their corresponding orthologue of HCMV using GAP alignment (PAM120) with a gap penalty of 14 and an extension penalty of 2. Signal peptides and transmembrane regions are boxed, identical sequences are white on black, and conservative changes are white on gray. Glycosylation sites are boldface and underlined. The asterisks indicate HCMV US2 residues that interact with MHC I (20). The black arrows indicate experimentally confirmed beta-sheets in US2 (A, B, C, C′, D, E, F, and G) (20). The gray arrows indicate predicted beta-sheets.