Table 3.
Summary of Results from Model 2 With Significant PM2.5 or NO2 by APOE Genotype Associations: Shown are Main Effects of Pollutant, APOE and Pollutant by APOE Interaction for the Significant Cognitive Factor
| Model 2 summary | beta Estimate se | 95% CI | Chi2 | p-value | |
|---|---|---|---|---|---|
| Past PM 2.5 *APOE and Executive Functions Factor | |||||
| Past PM2.5 | 0.02 | (0.01) | −0.0050, 0.0417 | 1.00 | 0.317 |
| APOE (REF ε4-) | 0.08 | (0.07) | −0.0464, 0.2128 | 1.57 | 0.209 |
| Past PM2.5*APOE | −0.06 | (0.02) | −0.0993,−0.0200 | 7.95 | 0.005 |
| Recent PM 2.5 *APOE and Executive Functions Factor | |||||
| Recent PM2.5 | 0.01 | (0.01) | −0.0070, 0.0365 | 0.83 | 0.362 |
| APOE (REF ε4-) | 0.09 | (0.07) | −0.0360, 0.2187 | 1.96 | 0.161 |
| Recent PM2.5*APOE | −0.05 | (0.02) | −0.0918,−0.0090 | 5.54 | 0.019 |
| Past PM 2.5 *APOE and Working Memory Sub-factor | |||||
| Past PM2.5 93–99 | 0.01 | (0.01) | −0.0108, 0.0404 | 0.84 | 0.360 |
| APOE (REF ε4-) | 0.09 | (0.07) | −0.0507, 0.2347 | 1.59 | 0.208 |
| Past PM2.5*APOE | −0.05 | (0.02) | −0.0927,−0.0111 | 5.82 | 0.016 |
| Recent PM 2.5 *APOE and Working Memory Sub-factor | |||||
| Recent PM2.5 | 0.01 | (0.01) | −0.0118, 0.0359 | 0.94 | 0.331 |
| APOE (REF ε4-) | 0.10 | (0.07) | −0.0440, 0.2350 | 1.79 | 0.181 |
| Recent PM2.5*APOE | −0.05 | (0.02) | −0.0896,−0.0053 | 4.73 | 0.030 |
| Past NO 2 *APOE and Episodic Memory Factor | |||||
| Past NO2 93–99 | −0.01 | (0.01) | −0.0200, 0.0067 | −0.98 | 0.329 |
| APOE (REF ε4-) | 0.01 | (0.08) | −0.1433, 0.1622 | 0.12 | 0.904 |
| Past NO2*APOE | 0.02 | (0.01) | 0.0043, 0.0422 | 2.41 | 0.016 |
| Recent NO 2 *APOE and Episodic Memory Factor | |||||
| Recent NO2 | −0.01 | (0.01) | −0.0235, 0.0063 | −1.13 | 0.259 |
| APOE (REF ε4-) | 0.03 | (0.08) | −0.1174, 0.1841 | 0.43 | 0.665 |
| Recent NO2*APOE | 0.03 | (0.01) | 0.0019, 0.0499 | 2.12 | 0.034 |
Notes. Summary results are from Model 2. Shown are the results for the pollutant, APOE ε4 status, and the pollutant by APOE interaction when the interaction is significant. Model 2 is run separately for the 4 pollutant measures predicting cognitive factors. Model 2 included the air pollutant, APOE ε4- status, the air pollutant by APOE ε4 interaction, air pollutant by time interaction covariates of time, location, age, lifetime education, race/ethnicity, household income, smoking status, alcohol consumption status, depressive symptoms, self-reported physician diagnosis of cardiovascular disease, diabetes, high cholesterol, and/or stroke. Full results for all Model 2 analyses (showing all variables in models) are in Supplemental Table 7.