Fig. 1.

Single-nucleus profiling of cardiac cells during DOX treatment. (a) Schematic diagram showing the single nucleus RNA-sequencing (snRNA-seq) experimental design and analytical workflow. (b) Heatmap of the expression of cell type-specific markers in the no-immune cell atlas (left) and uniform manifold approximation and projection (UMAP) plots of cardiac no-immune cells, colored by clusters (center) and treatment (right). (c) UMAP plots of cardiac cells from mice treated with DOX (20 mg/kg) or saline.