Fig. 1.
(A) Workflow of the study. LOC100294145 is first identified as the gene of interest with an integrative analysis. Its functions are then elucidated via various downstream analyses. (B) Manhattan plot showing the associations between all SNPs and the AD phenotype (AD cases vs non-atopic non-AD controls) after adjustment for age, gender and the first 10 principal components. Y-axis shows the p-value in log scale and x-axis shows the chromosomal position of each SNP. The red and the blue line represent the GWAS significant (p < 5 × 10−8) and GWAS suggestive threshold (p < 1 × 10−5) respectively