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Model of influenza virus RNA polymerase interacting with Pol II. The trimeric viral polymerase complex (PA, PB1, and PB2) interacts with the hyperphosphorylated form of Pol II either directly or indirectly by binding to the cellular capping machinery or to an as-yet-unknown protein (X) that interacts with the CTD. Phosphorylated serine 5 residues of the CTD are represented as red circles. The drawing is not to scale.
