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. 2023 Jul 26;28(10):4438–4450. doi: 10.1038/s41380-023-02188-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Standardized coefficients β (single patient regression), to detect Aβ (A)- and tau (T)- associated microglial activation, were correlated with clinical performance scores (Spearman’s correlation coefficient, r_s). For statistical calculations, 4RT, AD-CBS, and AD were pooled. = 4RT, = AD-CBS + AD. Correlation analyses were adjusted for sex, age, global-patient-TSPO-load (mean z-scores of 246 VOIs), and global-patient-AT-load (mean z-scores of 246 VOIs of the respective biomarker). No correction for multiple testing was applied. Subsequently, A and T were tested for interaction effects. AD Alzheimer’s disease, AD-CBS corticobasal syndrome with AD-pathology, 4RT four-repeat tauopathies, LAB low affinity binder, CTRL healthy controls, TSPO 18-kDa translocator protein, Aβ β-amyloid, GMV gray-matter-volume, MoCA Montreal-Cognitive-Assessment-Scale, MMSE Mini-Mental State Examination, UPDRS Unified-Parkinson’s-Disease-Rating-Scale (motor part), PSPRS Progressive-Supranuclear-Palsy-Rating-Scale, GDS Geriatric-Depression-Scale.

Inline graphic — Standardized coefficients β (single patient regression), to detect Aβ (A)- and tau (T)- associated microglial activation, were correlated with clinical performance scores (Spearman’s correlation coefficient, r_s). For statistical calculations, 4RT, AD-CBS, and AD were pooled. = 4RT, = AD-CBS + AD. Correlation analyses were adjusted for sex, age, global-patient-TSPO-load (mean z-scores of 246 VOIs), and global-patient-AT-load (mean z-scores of 246 VOIs of the respective biomarker). No correction for multiple testing was applied. Subsequently, A and T were tested for interaction effects. AD Alzheimer’s disease, AD-CBS corticobasal syndrome with AD-pathology, 4RT four-repeat tauopathies, LAB low affinity binder, CTRL healthy controls, TSPO 18-kDa translocator protein, Aβ β-amyloid, GMV gray-matter-volume, MoCA Montreal-Cognitive-Assessment-Scale, MMSE Mini-Mental State Examination, UPDRS Unified-Parkinson’s-Disease-Rating-Scale (motor part), PSPRS Progressive-Supranuclear-Palsy-Rating-Scale, GDS Geriatric-Depression-Scale.