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PD98059 blocks the replication of gD−/− mutant virus in J1-1 cells transduced with gD. J1-1 cells were exposed for 6 h to 10 PFU of baculovirus encoding gD driven by an immediate-early human cytomegalovirus promoter and then for 1 h to 30 μM of PD98059. The cells were then infected with 1.0 PFU of gD−/− mutant virus stock per cell and harvested 24 h after infection (panel A). Titers of progeny virus were determined on Vero-13R cells (panel B).
