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. 2023 Oct 11;271(2):631–641. doi: 10.1007/s00415-023-12023-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — White matter tract-specific T1 z-scores shown in two example early MS patients. Despite similar total lesion load, the patient on the left, whose EDSS increased over 2 years, presented more severe alterations of the NAWM compared the patient on the right, who was clinically stable. CST cortico-spinal tract; CT corticostriatal pathway; ML medial lemniscus; CC corpus callosum; ILF inferior longitudinal fasciculus; ICP inferior cerebellar peduncle; SST spinothalamic tract; TLC total lesion count; TLV total lesion volume; EDSS expanded disability status scale