Fig. 3.

Spearman correlations between white matter tract-specific metrics and EDSS in early (left half) and progressive MS (right half) cohorts. We estimated correlation of tract-specific lesion volume (LV, gray, first column) and T1 abnormalities in the NAWM (second column). We computed the average absolute z-score value in each tract (${\mu }_{|z|}$, teal). Correlations to EDSS₀ are shown in top rows and ΔEDSS in bottom rows. The inner circles represent the correlation of TLC (red) and TLV (gold). Red (/yellow) stars highlight tracts that yield to significantly higher (/lower) correlations to ΔEDSS compared to cross-sectional EDSS. Tract abbreviations are provided in the table. NAWM normal-appearing white matter; EDSS₀ expanded disability status scale, ΔEDSS change in EDSS after 2 years; TLC total lesion count; TLV total lesion volume; LV tract-specific lesion volume