Table 1.
Demographics and disease characteristics of healthy individuals and MS cohorts
| Parameter | Healthy cohort | Early MS | Progressive MS | W (p-value) |
|---|---|---|---|---|
| N (% female) | 92 (63%) | 47 (75%) | 52 (65%) | – |
| Age (years) | 37.3 ± 10.6 | 32.4 ± 8.0 | 49.8 ± 7.3 | 2255 (5.9 × 10–14) |
| Disease duration | – | 6.3 ± 5.4 months | 19.45 ± 7.8 years | 2346 (< 10–16) |
| EDSS0 | – | 1.87 ± 0.77 | 5.20 ± 0.89 | 2387 (< 10–16) |
| ΔEDSS | – | 0.01 ± 0.54 | 0.24 ± 0.55 | 1468 (0.037) |
| Δt [months] | – | 24.7 ± 1.3 | 25.0 ± 3.7 | 1488 (0.04) |
| TLV [mL] | – | 6.7 ± 8.7 | 14.3 ± 15.3 | 1721 (2 × 10–4) |
| TLC [# of lesions] | – | 22.2 ± 23.6 | 28.1 ± 15.9 | 1615 (0.003) |
The results of the Wilcoxon rank-sum test comparison between MS groups are reported in the last column
EDSS Expanded Disease Disability Scale; ΔEDSS EDSS change in 2 years; Δt time elapsed between clinical evaluations; TLV total lesion volume; TLC total lesion count