Table 2.

Single-cell targets from differentially expressed genes obtained from gene ontology biological processes for Noise + Hypothermia versus Noise + Normothermia.

Name		logFC	Value of p	Function	OHCs	SCs	SGNs	LW	Mono	Nphil	B-cell
1	Car2	1.07	1.2E-03	Zinc binding	2		−1	−1	−1	−1	−1
2	Cox8b	3.31	2.5E-03	Electron transport			−1	−1	−1	−1	−1
3	Crip1	0.67	3.7E-03	Zinc binding			2	2	2	2	2
4	Slc4a10	0.86	9.2E-03	Ion transport (Na)			2	−1
5	Tnnc2	2.72	7.1E-04	Calcium binding	−1
6	Tnnt1	2.62	1.6E-03	Muscle contraction	−1	−1		2	2	2
7	Tnnt2	0.94	5.1E-04		2	−1		2
8	Uqcr11	0.59	7.3E-03	Electron transport			1	1	2	2	−1
9	Uqcrb	0.63	9.7E-03				1	1	2	2	2
1	Cdo1	−0.93	1.4E-03	Iron binding			1	1
2	Chst11	−0.67	6.0E-03	Carbohydrate metabolism			−1	1	2
3	Csf2rb	−0.93	5.3E-04	Cytokine activity	2				2	2
4	Ccxl10	−2.21	4.1E-04		2	2			2
5	Fosl1	−1.96	1.3E-03	DNA binding				2
6	Gbp2	−1.23	5.0E-03	GTP binding				2
7	Gbp4	−1.62	4.4E-03					2			−1
8	Hcn1	−1.01	9.1E-03	Ion transport (Na, K)			2
9	Hmgcs2	−0.94	2.2E-03	Cholesterol metabolism		2	2	2
10	Ifi47	−1.19	2.3E-03	GTP binding							2
11	Ifit3	−1.58	1.5E-04	RNA binding			−1	2	2	2	2
12	Igtp	−0.99	1.5E-03	GTP binding			−1	1			−1
13	Il18bp	−1.04	1.8E-03	Cytokine activity				2
14	Isg15	−1.25	8.1E-04	Integrin-mediated signaling			1	2	2		−1
15	Kng2	−1.21	4.8E-05	Vasodilation		−1
16	Lbp	−1.54	9.2E-04	Lipid transport			2	2		−1
17	Lcn2	−2.88	2.2E-05	Ion transport (Fe)			2	2		−1
18	Mx2	−1.08	3.6E-04	GTP binding	2	2
19	Oasl2	−0.68	8.6E-03	RNA binding				2	2
20	Osmr	−1.31	3.1E-04	Cytokine activity	2	2		1
21	Pappa	−1.50	7.6E-03	Zinc binding	−1		1
22	Ptgs2	−1.21	9.1E-03	Iron binding	2	2
23	Serping1	−0.86	7.0E-03	Complement binding			2	2
24	Slc9a3	−0.75	9.7E-03	Ion transport (Na)	−1	2
25	Slpi	−1.07	8.6E-03	DNA binding	2	−1				2	−1
26	Socs3	−1.24	7.1E-03	Growth regulation	2	2	1	1	−1		2
27	Stat1	−0.83	6.7E-04	DNA binding			−1	2	−1	−1	2
28	Stat2	−0.65	4.6E-03	DNA binding	2	2	−1	2
29	Tap1	−0.94	3.1E-03	ATP binding				2	−1
30	Timp1	−1.48	2.3E-05	Cytokine activity			2	2
31	Vgf	−1.88	1.7E-03	Growth factor activity		−1	2

Summary of cellular targets associated with dysregulated DEGs involved in hypothermic neuroprotection post-noise. The organ of Corti single-cell types includes outer hair cells (OHCs), supporting cells (SCs), spiral ganglion neurons (SGNs), lateral wall cell types (LW), and inflammatory cells, such as monocytes (Mono), neutrophils (Nphil), and beta cells (B-cell). The LW cell types include cells from the stria vascularis (marginal, intermediate, and basal cells) and the spiral ligament (perivascular endothelial cells, root cells, and fibrocytes), whereas the spiral ganglion neurons comprise Type 1 (1A, 1B, and 1C) and Type 2 SGNs. Upregulated expression after noise is indicated in red, and downregulated expression is indicated in blue. Mixed differential gene expression within the LW and SGN subtypes is indicated in gray. Hypo. versus Normo. DEGs. logFC, log fold change.