TABLE 10.

Antibiotic efficacy in pregnant women with tularemia.

References	Country	Patient’s age (years) and weeks of gestation	Number or % of clinical forms	Antibiotics administered (number or % of patients)	Surgery for lymph node suppuration
Charles et al., 2008	USA	Pregnant, 29y	UG, tick-borne	Dox (1wk), then amc, azt, and dox (2 weeks). Became pregnant. Josamycin po, 3 weeks	Several needle aspirations
Dentan et al., 2013	France	Pregnant, 27y, 6 weeks	OP, skinning hunted rabbits	Amx for 3 weeks. Then, azt for 6 weeks	Lymph node excision
Yeşilyurt et al., 2013	Turkey	Pregnant, 26y, 18 weeks	OP	Ceftriaxone, then gen 10d, then cip 2 weeks	Several lymph node drainages
Yeşilyurt et al., 2013	Turkey	Pregnant, 31y, 23 weeks	OP+OG	2nd generation cephalosporin for 7d, then gen 10d, then cip 10d	Several lymph node drainages
Yeşilyurt et al., 2013	Turkey	Pregnant, 29y, 27 weeks	OP	Amc 7d, then gen, then cip 2 weeks	Lymph node drainage
Yeşilyurt et al., 2013	Turkey	Pregnant, 35y, 30 weeks	OP	Amc 10d, then gen, then cip 2 weeks	Lymph node drainage
Celik et al., 2013, 2014	Turkey	Pregnant, 18y, 16 weeks	OG	Cefuroxime 6 weeks	Lymph node drainage
Celik et al., 2013, 2014	Turkey	Pregnant, 27y, 18 weeks	OG	Amc, and eye drops (gen+cip)	Dacryocystitis and lymph node drainage
Johnsrud et al., 2019	USA	Pregnant, 26y, 18 weeks	UG, cat bite	Amx, azt	Lymph node drainage
Saranovic et al., 2023	Serbia	Pregnant, 33y, 18 weeks	GL	Gen 7d	Lymph node excision

All cases had good pregnancy outcome and gave birth to a healthy infant. Amx: amoxicillin; amc: amoxicillin plus clavulanic acid; azt: azithromycin; gen: gentamicin, dox: doxycycline, cip: ciprofloxacin. Tularemia forms: ulceroglandular (UG), glandular (GL), oropharyngeal (OP), oculoglandular (OG), pneumonic (PN), and typhoidal (TY).