TABLE 6.

Antibiotic efficacy in tularemia patients with predominant UG or GL forms.

References	Country	Patients’ number, male/ female, age range or mean	Number or % of clinical forms	Antibiotics administered (number or % of patients)	Lymph node suppuration and surgery (number, % of patients)	Failures, relapses, and complications (number, % of patients)
Evans et al., 1985	USA	88, 69m/19w, 2–82 years	66 UG, 22 TY	str, gen, tet, chl, or comb	NA	Relapses, Str (2/30,7%), gen (2/6), tet (3/6), chl (3/5), two deaths
Pérez-Castrillón et al., 2001	Spain	142, 53m/89w, 14–82 years, mean age 52 +/- 14 years	87 UG, 13 GL, 29 TY, 6 OG, 5 PN, 2 OP	Initial treatment: Str (94), cip (22), dox (14), others (6)	NA	Failures after initial treatment: Str (23.4%), cip (4.5%), dox (42.8%)
Weber et al., 2012	USA	121, 79m/42w women, 6 months–92 years	45 UG, 30 GL, 14 PN, 12 TY, 4 OG, 2 OP	tet (49%), amg (47%), flq (41%)	Surgery, (15, 12.4%)	Hospitalization, 58%; one death
Maurin et al., 2011	France	101, 55m/46w, mean age 51.7 years	34 UG, 24 GL, 17 OP, 4 OG, 10 PN, 9 TY, 3 comb	cip (18), lev (2), mox (1), dox (25), gen (1), comb (9)	NA	Relapses, (39/101, 38.6%); hospitalization (29.7%); one death
Darmon-Curti et al., 2020	France	177, 123m/54w, mean age 47.4 years	34.4% UG, 27.1% GL, 18% PN, 7.9% TY, 5% OP, 2.3% OG	dox, flq	Suppuration, (39, 22%); drainage, (31, 40.3%); excision, (47, 26.5%)	Failures, dox (9.9%), flq (33.3%); hospitalization (53.4%)
Kızıl et al., 2012	Turkey	19, 7m/12w, 4–75y, mean age 43.3 years	12 GL, 1 OG, 6 OP	str (8), cip (5), dox (3), others (3) for 11–90 days	Suppuration, (15, 78.9%), surgery, (11, 57.9%)	NA

str: streptomycin, gen: gentamicin, amg: aminoglycoside, tet: tetracycline, dox: doxycycline, flq: fluoroquinolone, cip: ciprofloxacin, lev: levofloxacin, mox: moxifloxacin, chl: chloramphenicol, comb: combined antibiotics. Tularemia forms: ulceroglandular (UG), glandular (GL), oropharyngeal (OP), oculoglandular (OG), pneumonic (PN), and typhoidal (TY).