TABLE 1.
Bacterial host and substrate targets of large clostridial toxins
| Toxin | Organism | Size (kDa) | Intracellular targets |
|---|---|---|---|
| TcdA | C. difficile | 308 | Rho, Rac, Cdc42 |
| TcdB | C. difficile | 270 | Rho, Rac, Cdc42 |
| TcsH | C. sordellii | 300 | Rho, Rac, Cdc42 |
| TcsL | C. sordellii | 270 | Ras, Rac, Rap, Ral, (Cdc42)b |
| Tcnα | C. novyi | 250 | Rho, Rac, Cdc42 |
| TcdB-1470a | C. difficile 1470 | 270 | Ras, Rac, Rap, Ral, Cdc42 |
a
TcdB-1470 is a hybrid between the TcdB cell entry domains and the TcsL enzymatic domain.
b
Glucosylation of Cdc42 is strain specific in C. sordellii.