Skip to main content
. 2023 Aug 7;46(1):1319–1330. doi: 10.1007/s11357-023-00886-3

Table 5.

Overview of the mediation analysis testing the mediation effect of frontal spindle activity during SO upstate on the significant association between spermidine plasma levels and AD score

Spermidine
AD score Estimate [95% CI] p value
Average causal mediation effect

1.75E−08

[− 5.74E−08, 0.00]

 0.65
Average direct effect

3.84E−07

[7.86E−08, 0.00]

 0.016*
Total effect

4.02E−07

[9.10E−08, 0.00]

 0.013*
Proportional effect

4.35E−02

[− 1.82E−01, 0.29]

 0.65

95% CI with lower and upper bound

AD Alzheimer’s disease, CI confidence interval, SO slow oscillation

*p value < 0.05; **p value < 0.01