Table 6.

Overview of the mediation analysis testing the mediation effect of central coupling strength on the significant association between spermidine plasma levels and AD score

	Spermidine
AD score	Estimate [95% CI]	p value
Average causal mediation effect	− 1.83E−09 [− 8.89E−08, 0.00]	0.93
Average direct effect	4.04E−07 [9.39E−08, 0.00]	0.013*
Total effect	4.02E−07 [9.02E−08, 0.00]	0.014*
Proportional effect	− 4.55E−03 [− 2.95E−01, 0.19]	0.92

95% CI with lower and upper bound

AD Alzheimer’s disease, CI confidence interval

*p value < 0.05; **p value < 0.0