Fig. 5.
Functional irreversibility of ICBM effect on ICa in DRG neurons. A Averaged (mean ± SEM) time-courses of ICa peak amplitude (ICa peak) recorded before, during, and after application of Cl-IB-MECA (30 nM) in Cl-IB-MECA pre-incubated (30 nM, 10 min, purple circles, n = 5) cells, in ICBM pre-incubated (1 µM, 10 min, green circles, n = 4) cells, or in not-incubated (empty circles, n = 10) cells. B Pooled data of ICa peak measured during baseline (bsl; i.e., before the Cl-IB-MECA application) in respective experimental groups. P value refers to one-way ANOVA, Bonferroni post hoc test vs not-incubated cells