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. 2023 Jun 29;46(1):1071–1082. doi: 10.1007/s11357-023-00854-x

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© The Author(s), under exclusive licence to American Aging Association 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — Hierarchical clustering of RNA sequencing of samples from the diabetic foot ulcer (DFU, n = 13) and uninvolved diabetic foot skin (DFS, n = 8) groups. a Heat map of sample-to-sample distances. b Heat map of count matrix. c Gene set enrichment analysis of hallmark gene set, with pathways enriched in DFU compared to DFS. d Gene set enrichment analysis of top 3 upregulated pathways in DFU (reactive oxygen species, TGF-β signaling, and TNF-α signaling via NF-κB), as well as apoptosis and p53 pathways