Fig. 3.

Arrow color represents activation (solid yellow) or inhibition (dashed blue) of target protein. Arrow thicknesses represents weight of interactions. Node colors represent node flows. Senescence-associated markers are boxed in black. a Uninvolved diabetic foot skin (DFS) edge-centered protein–protein interaction network. b Diabetic foot ulcer (DFU) prioritized protein–protein interaction network. c Significant edges, paths, and genes found in the prioritized protein–protein interaction networks of diabetic foot ulcers (DFU, n = 13), uninvolved diabetic foot skin (DFS, n = 8), or both. d Key edges, or protein–protein interactions, in the diabetic foot ulcer (DFU) network compared to the uninvolved diabetic foot skin (DFS) network. Senescence-associated markers are boxed in red