Table 4.

Relation between the amyloid burden of the temporal cortex and pathological, oxidative stress, inflammatory, and neurotrophic protein concentrations

Protein marker	Cognitively unimpaired				Alzheimer’s disease
	Unadjusted model		Adjusted model		Unadjusted model		Adjusted model
	β (SE)	p value	β (SE)	p value	β (SE)	p value	β (SE)	p value
Aβ40	6.89 (2.09)	0.004	6.79(2.01)	0.005	8.69 (3.65)	0.041	9.79 (3.99)	0.049
Aβ42	5.09(1.35)	0.001	4.79 (1.33)	0.002	6.53 (2.42)	0.021	8.86 (2.70)	0.011
F2-IP	− 0.03 (3.11)	0.993	1.88 (3.48)	0.594	1.46 (5.62)	0.804	2.34 (10.89)	0.844
Tau	− 3.58 (2.52)	0.171	− 2.74 (2.46)	0.279	− 5.13 (2.32)	0.055	− 5.67 (3.08)	0.115
pTau-181	− 0.21 (2.62)	0.938	− 0.06 (2.46)	0.981	8.52 (2.6)	0.007	9.05 (2.85)	0.011
IFNg	− 0.74 (2.18)	0.737	0.97 (2.18)	0.661	− 3.29 (3.75)	0.409	− 6.12 (4.84)	0.246
TNFα	− 0.82 (1.81)	0.653	− 3.09 (1.65)	0.075	6.98 (2.43)	0.017	8.41 (2.96)	0.025
RANTES	− 0.04 (1.98)	0.983	0.85 (1.92)	0.661	0.68 (4.61)	0.885	− 1.86 (8.17)	0.826
MIP1α	− 0.13 (2.14)	0.951	0.39 (2.07)	0.853	− 5.26 (4.11)	0.230	− 8.87 (6.04)	0.185
MCP-1	0.89 (2.53)	0.728	1.38 (2.54)	0.593	0.03 (4.31)	0.995	2.12 (8.43)	0.809
IL-7	− 2.89 (2.27)	0.216	− 4.80 (2.39)	0.058	− 0.57 (4.81)	0.907	− 3.29 (6.66)	0.634
IL-6	3.69 (2.68)	0.181	2.88 (2.92)	0.334	− 4.94 (3.73)	0.212	− 5.34 (4.88)	0.306
IL-10	0.98 (1.87)	0.605	2.72 (1.85)	0.158	− 6.75 (2.84)	0.037	− 8.10 (3.74)	0.061
VEGF	− 1.85 (2.51)	0.469	− 2.01 (2.38)	0.407	2.54 (4.07)	0.546	1.54 (5.81)	0.797

Multiple regression modeling was used to adjust for potential contributions of age, sex, and education years

β standardized β coefficient; SE standard error

Significant p values (< 0.05) are highlighted in bold