Table 1.

Overview of the characteristics of the study population

		Females			Males
		Mean / N	SD / %	N	Mean / N	SD / %	N
Characteristics
Study	FHS	665	62.6	1062	1,088	67.5	1612
	InCHIANTI	193	18.2		222	13.8
	BLSA	204	19.2		302	18.7
Age at sex hormone measurement	years	66.5	9.8	1062	62.4	12.2	1612
Age at DNA methylation	years	70.6	8.9	1062	66.9	11.6	1612
Time between visits among FHS	years	6.6	0.6	665	6.6	0.7	1088
Age of menopause	years	48.6	6.0	991	NA
Time since menopause at sex hormone measurements	years	17.3	11.0	991	NA
Smoking status at sex hormone measurements	never	437	40.7	1075	485	29.9	1624
	Former/ current	638	59.3		1,139	70.1
Packyears at sex hormone measurements among smokers	pack-years	17.8	18.4	638	24.1	20.8	1139
Alcohol intake	Drinks/ weeks	7.0	9.2	1015	19.4	24.2	1488
BMI at sex hormone measurement	kg/m2	27.5	5.2	1073	28.3	4.4	1622
Hormone levels
Total estrone	pg/ml	32.2	20.9	634	50.6	17.7	1037
Total estradiol	pg/ml	11.0	19.6	984	23.9	10.1	1519
SHBG	nmol/L	83.3	49.4	832	61.7	31.5	1260
Total testosterone	ng/dl	35.4	28.0	1017	541.3	226.6	1533
DHEAS	ug/dl	86.2	71.4	192	143.1	115.6	221
Bioavailable sex hormones
Bioavailable estrone	pg/ml	1.0	0.7	633	1.8	0.6	1037
Bioavailable estradiol	pg/ml	0.2	0.3	812	0.5	0.2	1250
Bioavailable testosterone	pg/ml	4.0	3.0	829	82.7	35.0	1259
Main outcome
Pheno AA	years	–0.7	6.4	1075	0.8	6.1	1624
Grim AA	years	–1.6	4.0	1075	1.7	4.5	1624
DNAm PAI1	pg/ml	19021	2862	1075	20865	3117	1624
DNAm Leptin	pg/ml	12026	2839	1075	4769	1648	1624

Abbreviations: N Number; SD Standard Deviation; years: years; NA Not applicable; FHS Framingham Heart Study; BLSA Baltimore Longitudinal Study of Aging