Table 2.

Linear mixed regression analysis with random intercept were performed to assess the effect of sex hormones on Pheno Age, GrimAge, DNAm-based PAI1, and DNAm-based leptin

Sex hormones were standardized and winsorized (highest and lowest 1%) by study. The analyses were performed stratified by sex, and adjusted for age, body mass index (BMI), alcohol intake, smoking packyears, physical activity, the time between visits, cohort study, and blood cell composition based on DNAm. Among women, we also adjusted for time since menopause

Abbreviations: Est Effect estimate; LL Lower Limit; UL Upper Limit; P P-value; BH-P Benjamini–Hochberg adjusted P-value; AA Age Acceleration; DNAm DNA-methylation; E1 total estrone; E2 total estradiol; SHBG Sex Hormone Binding Globulin; TotT total testosterone; TE ratio Total testosterone divided by total estradiol concentration