Table 1.

Experimental design

Intervention	Background	Sex	Number of mice	% increase in median survival	Reference
GHRKO	C57BL/6	Male	9	30	Bonkowski et al. (2006) [15]
		Female	9	30
Wild type (control)		Male	10	-
		Female	10	-
Snell DW	DW×C3H	Male	10	42	Flurkey et al. (2001) [16]
		Female	9	42
Wild type (control)		Male	12	-
		Female	9	-
Calorie restriction	UM-HET3	Male	14	32	Flurkey et al. (2010) [17]
		Female	12	40
Rapamycin		Male	14	13	Miller et al. (2014) [18]
		Female	13	21
Acarbose		Male	14	22	Harrison et al. (2014) [5]
		Female	13	5
Canagliflozin		Male	14	14	Miller et al. (2020) [7]
		Female	13	1
17α-estradiol		Male	14	12	Harrison et al. (2014) [5]
		Female	13	0
Untreated (control)		Male	26	-
		Female	26	-