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. 2023 Sep 25;46(2):1755–1773. doi: 10.1007/s11357-023-00938-8

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© The Author(s) 2023

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Fig. 2 — tRNA synthetase inhibitors upregulate ATF4 activity through Gcn2. A Drugs used in this study and their associated targets. B The amino acid response element measures ATF4 downstream activity. C–I Various tRNA synthetase inhibitors can increase ATF4 downstream activity (*p < 0.05, **p < 0.01, ***p < 0.001; Dunnett’s multiple testing procedure)