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. 2024 Jan 30;14:2508. doi: 10.1038/s41598-024-51735-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CGIs are enriched for compound MoA. (a) Table of screened compounds, gene target, Gene Ontology Biological Process (GO:BP) ID, GO:BP term that best represents compound MoA, and number of term-related genes found in the targeted library. (b) Enrichment of MoA related genes in compound CGI pairs. X-axis: log₂ fold enrichment. All: all CGIs, Negative: negative CGIs only, Positive: positive CGIs only. * represents p-value < 0.05. (c) Enrichment of MoA- related genes in compound CGI pairs for essential and non-essential genes. (d) Top: Guide-level LFC line plots across time points for CPT-MCM4. Orange: sgRNA 1, blue: sgRNA 2, green: sgRNA 3. Dotted line: DMSO; solid line: compound. Bottom: Barplot of raw differential LFC (dLFC) score for each guide. (e) Barplot categorizing 13 essential gene—compound interactions. See “Methods” for categorization approach.