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. 2024 Jan 18;35:1–16. doi: 10.1016/j.bioactmat.2024.01.009

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — DNA hydrogel-scaffold enhances in vitro angiogenesis. (a) The cytoskeleton of HUVECs after treated for 48 h. (b) Quantitative analysis of the cellular cytoskeleton. (c) Cell scratch experiment to verify the migration ability of HUVECs after treated for 24 h. (d) Quantitative analysis of migration. (e) Optical images of the capillary-like network formed by HUVECs after treated for 8 h on Matrix gel with the specimen-conditioned medium. (f) Quantification of points and circles formed by HUVECs after treated 8 h on the gel. (g) qRT-PCR experiments were conducted to validate the relative expression levels of genes (VWF, VEGFA, ANG 1, FGF, and SMAD 1) in each experimental group. *p < 0.05, **p < 0.01, and ***p < 0.001.