Fig. 6.

In vivo bone defect repair facilitated by the gel-scaffold constructs. (a) Schematic illustration of mouse cranial defect and treatment. (b) Micro-CT images depict cranial defects treated with constructs, encompassing both cross-sectional and longitudinal views. (c-e) Quantitative assessment of osteogenesis-related metrics, with BV indicating the volume of new bone, TV indicating the total volume of the defect, and BMD indicating the density of new bone. (f) Histological images stained with H&E exhibit cranial defects following the implantation of scaffold constructs for 4 and 8 weeks. *p < 0.05, **p < 0.01, and ***p < 0.001.