Table 1.

Therapeutic intervention for mitochondria in different liver models.

Therapeutics	Models	Main effects	Route of administration	Reference
Cilostazol	Ischemia-reperfusion injury	Increases PGC-1α expression and mtDNA content	Oral	134
Coenzyme Q10	Liver fibrosis	Enhances autophagy	Oral	143
Idebenone	Nonalcoholic steatohepatitis	Regulates lipid metabolism	Oral	133
Quercetin	Alcoholic liver disease, acute liver injury	Scavenges mitochondrial reactive oxygen species; increases the anti-apoptotic and anti-inflammatory potential	Oral	135,144
MitoQ	Hepatitis B virus	Decreases superoxide formation, restores immune function	Oral	111
Vitamin E	Nonalcoholic fatty liver disease	Reduces reactive oxygen species and alanine transaminase	Oral	136
Icaritin, dehydrocrenatidine, dichloroacetate	Hepatocellular carcinoma	Enhances mitophagy; recovers Δψm; inhibits mTOR complex 1; suppresses tumor growth	Oral	137,138,144
Mitochondria	Drug-induced liver injury	Reduces oxidative stress and apoptosis	Spleen injection	140
Mesenchymal stroma cells-extracellular vesicles	Nonalcoholic fatty liver disease, ischemia-reperfusion injury	Increases mitochondrial respiratory chain activity and adenosine triphosphate production	Injection	141,142