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. 2023 Jul 27;109(2):466–478. doi: 10.3324/haematol.2023.282897

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Figure 3. — Intratumoral IGH remodeling activity in the Sm-3’RRrec^Hi^gh chronic lymphocytic leukemia group. The Shannon diversity index was used to estimate class switch recombination (CSR), Sm-3’RR recombination (Sm-3’RRrec) and intra-clonal immunoglobulin heavy chain variable region (IGHV) diversities. (A) Higher Sm-3’RRrec junction diversity was observed in Sm-3’RRrec^High chronic lymphocytic leukemia (CLL) samples (N=11) compared to Sm-3’RRrec^Low (N=35) CLL and healthy peripheral blood mononuclear cells (PBMC) (N=9). (B) CSR junction diversity was increased in Sm-3’RRrec^High CLL samples (N=12) compared to Sm-3’RRrec^Lo^w (N=35) CLL and comparable to those of healthy PBMC (N=11). (C) CLL IGHV diversities were lower than those observed in diffuse large B-cell lymphomas (DL-BCL) harboring intra-tumoral subclones with divergent IGHV after somatic hypermutation (SHM) used as positive controls (N=10). Graphs represent the mean ± standard error of the mean. Statistical analyses were performed using unpaired t test. IGH: immunoglobulin heavy chain; 3’RR: 3’ regulatory region; NS: not significant; *P<0.05; **P<0.01; ***P<0.001.