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. 2023 Aug 10;109(2):493–508. doi: 10.3324/haematol.2023.283209

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Figure 2. — BCL3 expression in upstream and downstream tumors with BCL3 rearrangement. (A) RNA-sequencing data shows that BCL3 is upregulated in the upstream BCL3 tumors, except tumor 3646 carrying a subclonal t(14;19), compared to unmutated chronic lymphocyitc leukemia (U-CLL). Contrarily, the downstream BCL3 tumor (3676) upregulated NECTIN2 while showed lower BCL3 expression than any of the upstream and CLL tumors. (B) Immunohistochemistry images (400x) displaying a positive BCL3 expression in the further upstream tumor and in a representative upstream tumor, but not in a representative downstream tumor.