Figure 1.

Overview of the hPSC lines reported to carry a gain of (part of) chromosome 20

Each black line represents a separate cell line, and the length of the line indicates the size of the gain. The lines at the top of the ideogram represent the entire chromosome 20, with thin lines indicating trisomy and bold lines representing a gain through an isochromosome 20q. The black lines at the bottom represent cell lines with gains that start in the 20q11.21 region. The largest duplication begins at position 31,216,079 and ends at 35,871,578 based on build hg38, spanning 4.6 Mb. Information on the references and exact breakpoints of each cell line can be found in Table S1. The genes marked in yellow are discussed in detail in this review.