Figure 3.

Gene expression and number of publications related to tumorigenesis per gene on chromosome 20q11.21

The criteria for the most relevant genes to study in this review were gene expression data in primary tumors and number of publications in the PubMed database. Gene expression in primary tumor tissues from TCGA database was compared to gene expression in normal tissue from GTEx in the UCSC Xena online platform (Goldman et al., 2020). In the box and whisker plot, the box comprises from 25^th to 75^th percentiles, the whiskers extend from the hinge to the largest and smallest values no further than 1.5-times the inter-quartile range from the hinge, and the line indicates the median. Genes with higher expression were considered together with the number and quality of publications in PubMed. The search in PubMed database was filtered with the following search terms: (“gene name” [Title/Abstract]) AND ((cancer[Title/Abstract]) OR (tumor[Title/Abstract])). Results are shown in the bottom graph in the logarithmic scale. The genes that correspond to the criteria are ID1, BCL2L1, TPX2, HCK, PLAG2, POFUT1, DNMT3B, E2F1, and E2F6. Source data for the figure can be found in Table S3.