Table 2.
Plasma pharmacokinetic parameters of anthocyanins following administration of red grape juice and red wine.
| Anthocyanin | cmax (ng/mL) | tmax (h)a | AUC(0–3) (ng*h*mL−1) | t1/2 (h) | |
|---|---|---|---|---|---|
| Red grape juice | Cya-3-gluc | 0.42 (118) | 0.5 (0.5–0.5) | 0.60 (82.9) | 1.61 (22.7) |
| Del-3-gluc | 6.12 (66.7) | 0.5 (0.5–1.0) | 11.9 (55.0) | 1.72 (26.6) | |
| Malv-3-gluc | 48.8 (87.6) | 0.5 (0.5–1.0) | 71.7 (60.4) | 1.50 (34.4) | |
| Peo-3-gluc | 27.3 (51.0) | 0.5 (0.5–0.5) | 49.7 (36.2) | 1.63 (19.4) | |
| Pet-3-gluc | 16.1 (40.5) | 0.5 (0.5–0.5) | 31.5 (30.5) | 1.68 (48.8) | |
| Total anthocyaninsg | 100.1 (64.2) | 0.5 (0.5–1.0) | 168.4 (42.3) | 1.83 (28.5) | |
| Red wine | Cya-3-gluc | NA | NA | NA | NA |
| Del-3-gluc | NA | NA | NA | NA | |
| Malv-3-gluc | 18.5 (24.0) | 1.5 (1.0–1.5) | 40.4 (21.2) | 1.80 (31.9) | |
| Peo-3-gluc | 12.6 (16.1) | 1.5 (1.0–1.5) | 30.7 (17.7) | 1.83 (40.1) | |
| Pet-3-gluc | 12.3 (16.2) | 1.5 (0.5–1.5) | 29.1 (15.1) | 2.15 (22.9) | |
| Total anthocyaninsg | 42.9 (16.0) | 1.5 (1.0–1.5) | 100.8 (14.4) | 1.99 (28.1) | |
aMedian (range).
gSum of cyanidin 3-glucoside, delphinidin 3-glucoside, malvidin 3-glucoside, peonidin 3-glucoside, and petunidin 3-glucoside.
NA = not applicable (concentrations below LOQ).
Data are geometric means (with geometric coefficients of variation (%) in parentheses).