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. 2024 Jan 8;14:1298622. doi: 10.3389/fimmu.2023.1298622

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Copyright © 2024 Campos, Valois, Magalhães, Vasques, de Medeiros, Costa, Salgado Filho, Nogueira, Neves and Silva

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological findings show diffuse crescentic necrotizing glomerulonephritis with endocapillary proliferation and full-house immune complex deposition. Glomerulus with cellular crescent (arrow), endocapillary crescent and fibrinoid necrosis by light microscopy, Masson’s trichrome stain (A). Direct immunofluorescence demonstrates granular mesangial and capillary wall staining deposits of IgG (B), IgM (C), IgA (D), C3 (E), C1q (F), Fibrinogen (G), Kappa (H) e Lambda (I). Note the crescent surrounding the vascular tuft. Electron microscopy from paraffin embedded tissue reveals electron-dense deposits in the subendothelial (J) and mesangial (K) regions.