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. 2024 Jan 31;43:36. doi: 10.1186/s13046-024-02943-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — G6PD knockdown blocks DCBLD1-induced increases in cell proliferation, migration, and invasion. A Immunoblotting was used to detect DCBLD1 and G6PD levels in cell lysates. GAPDH was used as a loading control. B Cell viability was determined using CCK8 assays. C Cell proliferation rate was determined using clone formation assay. D Transwell migration and invasion assays were performed on HeLa and C33A cells, stably expressing vector, OV-DCBLD1, OV-DCBLD1-shCtrl, and OV-DCBLD1-shG6PD. E Xenograft tumor images derived from HeLa cells. n = 6 mice per group. Tumor growth curves of the different groups. Weight of the excised tumors in each group. Data are presented as mean ± SD. Statistical significance was assessed using a one-way ANOVA with the Brown-Forsythe test (B, C, and D) or an unpaired t test (E). (****, p < 0.0001; ***, p < 0.001). Scale bar: 50 µm