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. 2024 Jan 31;13:13. doi: 10.1186/s40164-023-00468-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — OGM causes ferroptosis in PDX models of GBM. (A) Known markers and mediators of ferroptosis were increased in PDX cells treated with OGM. (B) Known suppressors of ferroptosis were decreased in PDX cells treated with OGM. (C) ATF4 and CHAC1, involved in both ferroptosis and ER stress response, were increased in OGM treatment groups. (D) OGM and Erastin demonstrated very strong for induction of lipid peroxidation in Mayo6 cells. All treatments were highly significant with Chi-squared > 4, which is equal to p < 0.01) (E) At the concentrations used OGM and Erastin both caused significant cell death (F) OGM and Erastin demonstrated very strong induction of lipid peroxidation in Mayo39 cells. All treatments were highly significant with Chi-squared > 4, which is equal to p < 0.01) (G) At the concentrations used OGM and Erastin both caused significant cell death (H) OGM induced key markers of ferroptosis ATF4, CHAC1, HMOX1, TFRC, and SLC7A11, confirmed via qPCR in PDX lines