TABLE 2.
Vaccine-induced protection in the guinea pig model
| Immunization group | Log10 mean viable bacteria (right lung lobe) ± SEa | Log10 protection (lungs) | Log10 mean viable bacteria (spleen) ± SEb | Log10 protection (spleen) |
|---|---|---|---|---|
| PBS | 5.75 ± 0.16 | 0 | 5.58 ± 0.22 | 0 |
| BCG | 4.40 ± 0.10* | 1.35 | 2.30 ± 0.00* | 3.28 |
| MPL | 5.49 ± 0.22 | 0.26 | 5.10 ± 0.29 | 0.48 |
| MPL/CFP | 5.79 ± 0.25 | −0.03 | 5.16 ± 0.48 | 0.42 |
| MPL/CFP/IL-12 | 6.14 ± 0.19 | −0.39 | 5.36 ± 0.30 | 0.23 |
| MPL/CFP/IL-2 | 6.06 ± 0.17 | −0.31 | 5.90 ± 0.26 | −0.32 |
| MPL/CFP/IL-12/IL-2 | 5.21 ± 0.05* | 0.54 | 4.69 ± 0.23* | 0.89 |
| DNA-vector | 5.82 ± 0.07 | −0.07 | 5.80 ± 0.31 | −0.22 |
| DNA-Ag85A | 5.68 ± 0.20 | 0.07 | 5.00 ± 0.12 | 0.59 |
a
Bacterial counts in the right lower lung lobe of guinea pigs immunized with the indicated vaccines and aerogenically infected with M. tuberculosis 6 weeks after vaccination. Data are represented as the mean CFP/right lung lobe ± standard error (n = 4). Asterisks represent statistical significance (P < 0.05) based on the unpaired, two-tailed Student t test.
b
Bacterial counts in the spleens of guinea pigs immunized with the indicated vaccines and aerogenically infected with M. tuberculosis 6 weeks after vaccination. Data are represented as the mean CFP/spleen ± standard error (n = 4).