TABLE 3.
Group | Time to death (days)/bacterial load (log) in animal:
|
|||
---|---|---|---|---|
1 | 2 | 3 | 4 | |
PBS | 98/7.84 | 103/7.45 | 138/5.87 | NDa,b/NAg |
MPL | 61/8.01 | 74/8.46 | 94/7.04 | 221d/4.84 |
MPL-CFP | 126/7.46 | 126/7.62 | 136/7.07 | 221d/4.45 |
MPL–CFP–IL-2–IL-12 | 79/NDc | 82/6.43 | 109/NDc | 140/5.93 |
MPL–CFP–IL-12 | 70/7.05 | 109/7.41 | 139/6.71 | 172/NDc |
MPL–CFP–IL-2 | 131/8.24 | 181/NDc | 221d/6.58 | 221d/4.79 |
DNA-Ag85A | 89/NDc | 194e/7.82 | 221d/6.69 | 221d/6.16 |
DNA-vector | NDb/NA | 55/7.61 | 127/7.15 | 177/NDc |
BCG | 221d/3.31 | 221d/4.19 | 221d/6.54f | 221d/4.77 |
ND, not determined.
Animal died before aerosol challenge for unknown reasons.
Animal died overnight and the tissues autolysed.
Animal survived length of experiment [221 days].
Animal had extensive lymphadenopathy or lymphoma.
Animal was starting to lose weight.
NA, not applicable.