Table 2.

Quantitative metrics of cortical atrophy by region in the MGH and LEADS cohorts.

	MGH				LEADS
	Mean thickness: mm (SD)				Mean thickness: mm (SD)
	EOAD (n = 25)	CN (n = 25)	Group mean difference (mm)	Effect size (d)	EOAD (n = 211)	CN (n = 88)	Group mean difference (mm)	Effect size (d)
Inferior parietal	1.90 (0.18)	2.31 (0.13)	−0.41***	−2.63	2.16 (0.19)	2.46 (0.11)	−0.3***	−1.87
Precuneus	1.88 (0.16)	2.26 (0.12)	−0.38***	−2.65	2.16 (0.20)	2.46 (0.11)	−0.3***	−1.82
Caudal lateral temporal	2.14 (0.18)	2.57 (0.14)	−0.43***	−2.7	2.38 (0.19)	2.67 (0.12)	−0.29***	−1.79
Posterior cingulate	2.19 (0.19)	2.61 (0.12)	−0.41***	−2.57	2.38 (0.19)	2.64 (0.13)	−0.26***	−1.66
Superior parietal	1.73 (0.18)	2.08 (0.10)	−0.34***	−2.32	2.02 (0.21)	2.27 (0.11)	−0.25***	−1.48
Mid lateral temporal	2.33 (0.22)	2.70 (0.14)	−0.37***	−2.03	2.44 (0.20)	2.68 (0.14)	−0.24***	−1.37
Middle frontal	1.98 (0.22)	2.33 (0.16)	−0.35***	−1.82	2.18 (0.18)	2.37 (0.13)	−0.19***	−1.23
Superior frontal	2.07 (0.18)	2.36 (0.11)	−0.29***	−1.92	2.32 (0.16)	2.49 (0.11)	−0.17***	−1.17
Fusiform	2.57 (0.28)	3.04 (0.24)	−0.47***	−1.81	2.78 (0.30)	3.00 (0.19)	−0.22***	−0.85
Primary visual	1.63 (0.13)	1.57 (0.12)	0.06	0.47	1.77 (0.19)	1.73 (0.16)	0.04	0.22

Note: Effect size = Cohen’s d.

^***p < .001