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. 2023 Aug 9;4(1):336–345. doi: 10.1016/j.bpsgos.2023.08.001

Figure 1.

Figure 1

Sickness and recovery after CLP with and without corticosteroid treatment. (A) Experimental timeline. (B) (Left panel) Baseline locomotion. (Right panel) One day after surgery, CLP mice were less active than sham mice (n = 40 mice/group). (C) Corticosterone treatment prevented weight loss in CLP animals in the week immediately after surgery; CLP animals that were treated with vehicle lost more weight than the 4 other groups (VEH+sham: n = 20; CORT+sham: n = 17; VEH+CLP: n = 12; CORT+CLP: n = 15). On day 21, 3 weeks after CLP, there was no significant difference in weight change from baseline between groups (sham: n = 20, CLP: n = 18). Error bars show standard error of the mean. ∗p < .05 relative to all other groups based on post hoc tests, ∗∗∗∗p < .0001. CLP, cecal ligation and puncture; CORT, corticosterone; EZM, elevated zero maze; FST, forced swim test; OF, open field; OR, object recognition; VEH, vehicle.