Figure 2.
Plasma palmitate, VLDL-TG, and VLD-apoB kinetics in women with low and high amounts of detectable BAT
(A and B) Plasma palmitate Ra (A) and plasma clearance rate (B) in the LBAT (n = 9) and HBAT (n = 10) groups.
(C–F) VLDL-TG secretion rate (C), plasma clearance rate (D), VLDL-apoB secretion rate (E), and plasma clearance rate (F) in the LBAT (n = 11) and HBAT (n = 14) groups. VLDL-TG and VLDL-apoB kinetics were assessed by using intravenous infusion of stable isotopically labeled glycerol and leucine tracers and compartmental modeling analysis. A smaller number of participants completed assessment of fatty acid kinetics, as this assessment was added later in the study protocol.
ApoB, apolipoprotein B; BAT, brown adipose tissue; HBAT, high-BAT group, BAT volume ≥20 mL; LBAT, low-BAT group, BAT volume <20 mL; Ra, rate of appearance; VLDL-TG, very-low-density lipoprotein triglycerides. Data are means ± SD for normally distributed data or median (interquartile range) for skewed data. p values for between-group comparisons were determined by using Student’s t test (normally distributed data) or the Mann-Whitney U test (skewed data). ∗p < 0.05. Related to Figures S2 and S5.