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. 2024 Jan 17;626(7997):151–159. doi: 10.1038/s41586-023-06922-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, The human and mouse ZRS sequence is highly conserved. The human ZRS has 19 putative ETS-binding sites, all with affinities equal to or lower than 0.52. The mouse ZRS has 6 functionally validated and 12 putative ETS sites; 15 of these are conserved in location and affinity with the human ZRS. b, The ETS-A site and surrounding sequence show perfect conservation between mouse and human, as indicated by asterisks. Blue box highlights the ETS-A sequence within the human and mouse ZRS.