Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 12;626(7997):212–220. doi: 10.1038/s41586-023-06936-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 3 — a, Chromatin accessibility profile near CG15117 gene. b, In vivo enhancer activity of the wild-type (WT) CG15117 enhancer. c, CG15117 enhancer prediction scores for each cell type (top) and prediction scores for the γ-KC and T1 classes after each mutational step. d, Nucleotide contribution scores of WT CG15117 enhancer sequence and after 14 mutations for T1 (top) and γ-KC (bottom). e, Nucleotide contribution scores of WT amon enhancer sequence and after 13 mutations for T4 (top) and γ-KC (bottom). f, In vivo enhancer activity of the WT CG15117 enhancer and after 14 mutations. The CG15117 enhancer showed a slightly altered T1 pattern following incorporation of the KC code. g, Nucleotide contribution scores of WT Pkc53e enhancer sequence and after 9 mutations for T2 (top), T1 (middle) and γ-KC (bottom). In b, e, the expected location of KC is shown with dashed circles. Scale bars, 100 µm. In d,f,g, the position of the mutations is shown with dashed lines, the mutational order is written in between top and bottom plots and motif annotation is indicated with strong (s) or weak (w) motif instances.